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In one study in mice, large amounts of allopurinol caused birth defects and other unwanted effects. The product of methylation, 2-amino-6-methylthiopurine, is also substantially less active and less toxic than Thioguanine and its formation is likewise unaffected by the presence of allopurinol. This pathway of Thioguanine inactivation is not dependent on the action of xanthine oxidase, and an inhibitor of that enzyme (such as allopurinol) will not block the detoxification of Thioguanine even though the inactive 6-thioxanthine is normally further oxidized by xanthine oxidase to thiouric acid before it is eliminated. After you have been taking allopurinol regularly for several months, the attacks may stop completely. There are no data with Augmentin and allopurinol administered concurrently.
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